2024
Li J+, Sae Her A+, Besch A+, Ramirez-Cordero B, Crames M, Banigan JR, Mueller C, Marsiglia WM, Zhang Y, Traaseth NJ (+equal contribution)
Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE.
Nature Communications, 2024, 15: 4537. [pdf]
Li J, Li Y, Koide A, Kuang H, Torres VJ, Koide S, Wang DN, Traaseth NJ
Proton-coupled transport mechanism of the efflux pump NorA.
Nature Communications, 2024, 15: 4494. [pdf]
2023
Traaseth NJ
Chapter 8: Multiple acquisition strategies.
Two-dimensional NMR methods, 2023, Wiley. [pdf]
Besch A, Marsiglia WM, Mohammadi M, Zhang Y, Traaseth NJ.
Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state.
PNAS, 2023, 20 (8) e2213090120. [pdf]
*Press Release from NYU, NSF news, and additional coverage.
2022
Wallon L, Khan I, Teng KW, Koide A, Zuberi M, Li J, Ketavarapu G, Traaseth NJ, O’Bryan JP, Koide S.
Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket.
PNAS, 2022, 119: e2204481119. [pdf]
Jiang L, Zuo X, Li J, Traaseth NJ, Kirshenbaum K.
Programmed supramolecular assemblies using orthogonal pairs of heterodimeric coiled coil peptides.
Angew Chemie Int Ed, 2022, 61: e202201895. [pdf]
Brawley DN, Sauer DB+, Li J+, Zheng X+, Koide A+, Jedhe GS, Suwatthee T, Song J, Liu Z, Arora PS, Koide S, Torres VJ, Wang DN, Traaseth NJ (+equal contribution)
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nature Chemical Biology, 2022, 18: 706-712. [pdf]
*Highlighted in News & Views in Nature Chemical Biology and Press Release from the NYU School of Medicine
2021
Li J+, Sae Her A+, Traaseth NJ (+equal contribution)
Asymmetric protonation of glutamate residues drives a preferred transport pathway in EmrE.
PNAS, 2021, 118: e2110790118. [pdf]
2020
Li J+, Sae Her A+, Traaseth NJ (+equal contribution)
Site-specific resolution of anionic residues in proteins using solid-state NMR spectroscopy.
J Biomolec NMR, 2020, 74: 355-363. [pdf]
Chen L+, Marsiglia WM+, Chen H+, Katigbak J, Erdjument-Bromage H, Kemble DJ, Fu L, Ma J, Sun G, Zhang Y, Liang G, Neubert TA, Li X, Traaseth NJ*, Mohammadi M* (+equal contribution)
Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation.
Nature Chemical Biology, 2020, 16(3): 267-277. [pdf]
Marsiglia WM, Qamra R, Jackson KM, Traaseth NJ
A CURE biochemistry laboratory module to study protein-protein interactions by NMR spectroscopy.
Journal of Chemical Education, 2020, 97(2), 437-442. [pdf]
2019
Leninger M+, Sae Her A+, Traaseth NJ (+equal contribution)
Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations.
eLife, 2019, 8:e48909. [pdf]
Marsiglia WM, Katigbak J, Zheng S, Mohammadi M, Zhang Y, Traaseth NJ
A Conserved Allosteric Pathway in Tyrosine Kinase Regulation.
Structure, 2019, 27(8):1308-1315. [pdf]
Yang W, Lee JS, Leninger M, Windschuh J, Traaseth NJ, Jerschow
A Magnetization Transfer in Liposome and Proteoliposome Samples that Mimic the Protein and Lipid Composition of Myelin.
NMR in Biomedicine, 2019, 32, e4097. [pdf]
2018
Leninger M+, Marsiglia WM+, Jerschow A, Traaseth NJ (+equal contribution)
Multiple Frequency Saturation Pulses Reduce CEST Acquisition Time for Quantifying Conformational Exchange in Biomolecules.
Journal of Biomolecular NMR, 2018, 71, 19-30. [pdf]
Gao A, Vasiley N, Luciano DJ, Levenson-Palmer R, Richards J, Marsiglia WM, Traaseth NJ, Balasco JG, Serganov
A Structural and Kinetic Insights into Stimulation of RppH-Dependent RNA Degradation by the Metabolic Enzyme DapF.
Nucleic Acids Res, 2018, 46, 6841-6856. [pdf]
Banigan JR, Leninger M, Sae Her A, Traaseth NJ
Assessing Interactions Between a Polytopic Membrane Protein and Lipid Bilayers Using Differential Scanning Calorimetry and Solid-State NMR.
Journal of Physical Chemistry B, 2018, 122, 2314-2322. [pdf]
Leninger M, Traaseth NJ
NMR Spectroscopy Approach to Study the Structure, Orientation, and Mechanism of the Multidrug Exporter EmrE.
Methods Mol Biol, 2018, 1700, 83-96. [pdf]
Abramov G, Traaseth NJ
Afterglow Solid-State NMR Spectroscopy.
Methods Mol Biol, 2018, 1686, 55-66. [pdf]
2017
Chen H+, Marsiglia WM+, Cho M-K, Huang Z, Deng J, Blais SP, Gai W, Bhattacharya S, Neubert TA, Traaseth NJ*, Mohammadi M* (+equal contribution)
Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
eLife, 2017, 6, pii: e21137. doi: 10.7554/eLife.21137. [pdf]
2016
Craven TW, Cho M-K, Traaseth NJ, Bonneau R, Kirshenbaum K
A Miniature Protein Stabilized by a Cation-π Interaction Network Core.
J Am Chem Soc, 2016, 138, 1543-50. [pdf]
Gayen A+, Leninger M+, Traaseth NJ (+equal contribution)
Protonation of a Glutamate Residue Modulates the Dynamics of the Drug Transporter EmrE.
Nature Chemical Biology, 2016, 12, 141-145. [pdf] Featured as cover article [link]
Huang Z, Marsiglia WM, Roy UB, Rahimi N, Ilghari, Wang H, Chen H, Gai W, Blais S, Neubert TA, Mansukhani A, Traaseth NJ, Li X, Mohammadi M
Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cg.
Molecular Cell, 2016, 61, 98-110. [pdf]
2015
Traaseth NJ, Banigan JR, Leninger M Exploring Transporters within the Small Multidrug Resistance Family Using Solid-State NMR Spectroscopy. eMagRes, 2015, 4, 551-9. [pdf]
Banigan JR, Gayen A, Cho MK, Traaseth NJ A Structured Loop Modulates Coupling Between the Substrate-Binding and Dimerization Domains in the Multidrug Resistance Transporter EmrE. Journal of Biological Chemistry, 2015, 290, 805-14. [pdf] 
Banigan JR, Gayen A, Traaseth NJ Correlating Lipid Bilayer Fluidity with Sensitivity and Resolution of Polytopic Membrane Protein Spectra by Solid-State NMR Spectroscopy. Biochim Biophys Acta, 2015, 1848, 334-41. [pdf] 
2014
Cho MK+, Gayen A+, Banigan JR, Leninger M, Traaseth NJ The Intrinsic Conformational Plasticity of Native EmrE Provides a Pathway for Multidrug Resistance. J Am Chem Soc, 2014, 136, 8072-80. (+equal contribution) [pdf]
2013
Kushal S, Lao BB, Henchey LK, Dubey R, Mesallati H, Traaseth NJ, Olenyuk BZ, Arora PS Protein Domain Mimetics as in vivo Modulators of Hypoxia-Inducible Factor Signaling. Proc Natl Acad Sci, 2013, 110, 15602-7. [pdf]
Gayen A, Banigan JR, Traaseth NJ Ligand-Induced Conformational Changes of the Multidrug Resistance Transporter EmrE Probed by Oriented Solid-State NMR Spectroscopy. Angew Chemie Int Ed, 2013, 52, 10321-4. [pdf] Featured on back-cover
Chen H, Huang Z, Dutta K, Blais S, Neubert TA, Li X, Cowburn D, Traaseth NJ, Mohammadi M Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Pathogenic Gain-of-Function Mutations. Cell Reports, 2013, 4(2), 376-84. [pdf] F1000 Article Recommendation
Banigan JR, Gayen A, Traaseth NJ Combination of 15N Reverse Labeling and Afterglow Spectroscopy for Assigning Membrane Protein Spectra by Magic-Angle-Spinning Solid-State NMR: Application to the Multidrug Resistance Protein EmrE. Journal of Biomolecular NMR, 2013, 55, 391-9. [pdf]
2012
Banigan JR and Traaseth NJ Using Afterglow Magnetization from Cross-Polarization Magic-Angle-Spinning Solid-State NMR Spectroscopy to Obtain Simultaneous Heteronuclear Multidimensional Spectra. Journal of Physical Chemistry B, 2012, 116, 7138-44. [pdf]
Traaseth NJ, Chao F.A., Masterson LR, Mangia S, Garwood M, Michaeli S, Seelig B, Veglia G Heteronuclear Adiabatic Relaxation Dispersion (HARD) for Quantitative Analysis of Conformational Dynamics in Proteins. J Magn Reson, 2012, 219, 75-82. [pdf]
Verardi R, Traaseth NJ, Masterson LR, Vostrikov VV, Veglia G Isotope Labeling for Solution and Solid-state NMR Spectroscopy of Membrane Proteins. Adv Exp Med Biol, 2012, 992, 35-62. [pdf]