Breast Cancer Imaging
Development of Fast Imaging System for Detection of Breast Cancer and Therapy Monitoring
The goal of the Breast Imaging Project is to design and validate an instrument for rapid optical imaging using digital detection techniques. The breast imager was recently completed, employing digital detection techniques that include multiple digital signal processor (DSP) chips for processing data. Configured in a master-slave architecture, these DSP chips can streamline data collection while minimizing cost, improving scalability, and maintaining low noise levels. Multiple clinical trials have been undertaken at Columbia University with the Breast Imaging system, including a study to evaluate the ability to detecting breast cancer using dynamic optical imaging, a pre-clinical study monitoring early tumor response to anti-angiogenic therapy, and a clinical study monitoring individual patient response to neo-adjuvant chemotherapy.
- L. Altoe, A. Marone, H.K. Kim, K. Kalinsky, D.L. Hershman, A.H. Hielscher, and R.S. Ha, “Diffuse optical tomography of the breast: a potential modifiable biomarker of breast cancer risk with neoadjuvant chemotherapy,” Biomedical Optics Express 10(8), pp. 4305-4315 (2019). PMID: 31453012; PMCID: PMC6701514; <https://doi.org/10.1364/BOE.10.004305
- E. Gunther, E. Lim, H.K. Kim, M. Flexman, J.A. Campbell, H. Hibshoosh, K. Crew, K. Kalinsky, D.L. Hershman, A.H. Hielscher, “Dynamic diffuse optical tomography for monitoring neoadjuvant chemotherapy in breast cancer patients,” Radiology 2018 Jun; 287(3):778-786. Epub 2018 Feb 12; PMID: 29431574; PMCID: PMC5978455 [Available on 2018-06-01]; <https://doi.org/10.1148/radiol.2018161041>
- E.A. Lim, J.E. Gunther, H.K. Kim, M. Flexman, H. Hibshoosh, K. Crew, B. Taback, J. Campbell, K. Kalinsky, A.H. Hielscher, D.L. Hershman, “Diffuse optical tomography changes correlate with Residual Cancer Burden after neoadjuvant chemotherapy in breast cancer patients” Breast Cancer Research and Treatment 162(3), pp. 533-540 (April 2017); PMID: 28190249; <https://doi.org/10.1007/s10549-017-4150-7>
- M.L. Flexman, H.K. Kim, J.E. Gunther, E.A. Lim, M.C. Alvarez, E. Desperito, K. Kalinsky D.L. Hershman, A.H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” Journal of Biomedical Optics 18(9), 096012 (Sep 18, 2013). <https://doi.org/10.1117/1.JBO.18.9.096012> PMID: 24048367
- M.L. Flexman, M.A. Khalil, R. Al Abdi, H.K. Kim, C.J. Fong, E. Desperito, D.L. Hershman, R.R. Barbour, A.H. Hielscher, “Digital optical tomography system for dynamic breast cancer imaging,” Journal of Biomedical Optics 16(7), 076014 (July 2011); [doi:10.1117/1.3599955] PMID: 21806275