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Due to the well-known “fluorine effect” of the fluorine atom and the fluorinated groups on the chemical, physical and biological properties of a given molecule, incorporation of a fluorine atom or a fluoroalkyl group into has become a routine practise in the development of drugs or agrochemicals. Consequently, development of efficient methods that could late-stage introduction of fluorine or fluorinated groups of the drug molecules has been of intense current interests.

Among the rapidly increasing and powerful fluoroalkylating methods, nucleophilic or radical fluoroalkylations arguably represent two of the most versatile and actively studied methods and in the past several decades, tremendous progress has been achieved that allows effective introduction of fluoroalkyl groups. An alternative yet straightforward strategy by direct fluoroalkylation of a nucleophile with an electrophilic fluoroalkylating reagent in the presence or absence of a transitional metal catalyst has generally been considered as an equally effective method for the preparation of fluoroalkylated compounds. Thus, development of new reactive electrophilic fluoroalkylating reagents that could be synthesized highly efficiently remains a considerable unmet need.In the past 7 years, we have discovered a new family of electrophilic fluoroalkylating reagents. These reagents can be easily synthesized and stable as solids. yet, they are super reactive in solution. The low cost and structural flexibility of these compounds make them idea reagents for late stage fluoroalkylation.

General Organic Chemistry Iⅈ Organic Chemistry Lab

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Summer

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At least 40 h/week

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Shanghai Institute of Organic Chemistry

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Yes, 1000 RMB

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shenql@sioc.ac.cn