[go to list of publications from Pubmed] [go to Google Scholar page]

Ziv N, Shuster BM, Siegal ML and Gresham D. 2017. Resolving the complex genetic basis of phenotypic variation and variability of cellular growth. Genetics 206:1645-1657. [link]
Siegal ML. 2017. Molecular genetics: Chaperone protein gets personal. Nature 545:36-37. [link]
Geiler-Samerotte KA and Siegal ML. 2016. Questioning buffering. Cell Systems 3:407. [link]
Geiler-Samerotte KA, Zhu YO, Goulet BE, Hall DW and Siegal ML. 2016. Selection transforms the landscape of genetic variation interacting with Hsp90. PLOS Biology 14:e2000465. [link] [primer link]
Rauscher E, Conley D and Siegal ML. 2015. Sibling genes as environment: Sibling dopamine genotypes and adolescent health support frequency dependent selection. Social Science Research 54:209-220. [link]
O’Malley MA, Soyer OS and Siegal ML. 2015. A philosophical perspective on evolutionary systems biology. Biological Theory 10:6-17. [link]
Siegal ML. 2015. Shifting sugars and shifting paradigms. PLoS Biology 13:e1002068. [link]
Bauer CR, Li S and Siegal ML. 2015. Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness. Molecular Systems Biology 11:773. [link]
Calcott B, Levy A, Siegal ML, Soyer O and Wagner A. 2015. Engineering & biology: counsel for a continued relationship. Biological Theory 10:50-59. [link]
Siegal ML and Leu J-Y. 2014. On the nature and evolutionary impact of phenotypic robustness mechanisms. Annual Review of Ecology, Evolution, and Systematics 45:495-517. [link]
Arbeitman M, Kopp A, Siegal ML and Van Doren M. 2014. The genetics of sex: exploring differences. Genetics 197:527-529. [link]
Zhu YO, Siegal ML, Hall DW and Petrov DA. 2014. Precise estimates of mutation rate and spectrum in yeast. Proc Natl Acad Sci USA 111:E2310-8. [link]
Also see:
Zhu YO, Siegal ML, Hall DW and Petrov DA. 2014. Reply to Chen and Zhang: On interpreting genome-wide trends from yeast mutation accumulation data. Proc Natl Acad Sci USA 111:E4063. [link]
Conley D, Domingue B, Harris KM, McQueen M, Siegal ML and Boardman J. 2014. Testing the key assumption of heritability estimates based on genome-wide genetic relatedness. Journal of Human Genetics 59:342-5. [link]
Siegal ML. 2014. Systems Biology, in Oxford Bibliographies in Evolutionary Biology, Losos J, ed. New York: Oxford University Press. [link]
Siegal ML. 2013. Evolution of molecular networks, in The Princeton Guide to Evolution, Losos J, ed. Princeton: Princeton University Press. [link]
Ziv N, Siegal ML and Gresham D. 2013. Genetic and non-genetic determinants of cell-growth variation assessed by high-throughput microscopy. Molecular Biology and Evolution 30:2568-2578. [link]
Richardson JB, Uppendahl LD, Traficante MK, Levy SF and Siegal ML. 2013. Histone variant HTZ1 shows extensive epistasis with, but does not increase robustness to, new mutations. PLOS Genetics 9:e1003733. [link]
Conley D, Rauscher E, Dawes C, Magnusson PKE and Siegal ML. 2013. Heritability and the equal environments assumption: evidence from multiple samples of misclassified twins. Behavior Genetics 43:415-426. [link]
Geiler-Samerotte K, Bauer C, Li S, Ziv N, Gresham D and Siegal ML. 2013. The details in the distributions: why and how to study phenotypic variability. Current Opinion in Biotechnology 24:752-759. [link]
Conley D, Rauscher E and Siegal ML. 2013. Beyond Orchids and Dandelions: Testing the 5-HTT “Risky” Allele for Evidence of Phenotypic Capacitance and Frequency-Dependent Selection. Biodemography and Social Biology 59:37-56. [link]
Siegal ML. 2013. Crouching variation revealed. Molecular Ecology 22:1187-1189. [link]
Schnakenberg SL, Siegal ML and Bloch Qazi MC. 2012. Oh, the places they’ll go: female sperm storage and sperm precedence in Drosophila melanogaster. Spermatogenesis 2:224-235. [link]
Fraser HB, Levy S, Chavan A, Shah HB, Kowli S, Perez JC, Zhou Y, Siegal ML and Sinha H. 2012. Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity. Genome Research 22:1930-1939. [link]
Levy SF and Siegal ML. 2012. The robustness continuum, pp. 431-452 in Evolutionary Systems Biology, Soyer O, ed. New York: Springer, Advances in Experimental Medicine and Biology Series, Volume 751. [link]
Siegal ML and Rushlow C. 2012. Pausing on the path to robustness. Developmental Cell 22:905-906. [link]
Levy SF, Ziv N and Siegal ML. 2012. Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant. PLoS Biology 10:e1001325. [link] [synopsis link]
Siegal ML and Masel J. 2012. Hsp90 depletion goes wild. BMC Biol 10:14. [link]
Schnakenberg SL, Matias WR and Siegal ML. 2011. Sperm-storage defects and live birth in Drosophila females lacking spermathecal secretory cells. PLoS Biology 9:e1001192. [link] [primer link]
Chatterjee SS, Uppendahl LD, Chowdhury MA, Ip PL and Siegal ML. 2011. The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. Development 138:1099-1109. [link]
Arbeitman MN, Kopp A, Siegal ML and Van Doren M. 2010. Everything you always wanted to know about sex … in flies. Sex Dev 4:315-320. [link]
Chen K, van Nimwegen E, Rajewsky N and Siegal ML. 2010. Correlating gene expression variation with cis-regulatory polymorphism in Saccharomyces cerevisiae. Genome Biol Evol 2:697-707. [link]
Masel J and Siegal ML. 2009. Robustness: mechanisms and consequences. Trends Genet 25:395-403. [link]
Chen K, Maaskola J, Siegal ML and Rajewsky N. 2009. Reexamining microRNA site accessibility in Drosophila: a population genomics study. PLoS ONE 4:e5681. [link]
Levy SF and Siegal ML. 2008. Network hubs buffer environmental variation in Saccharomyces cerevisiae. PLoS Biology 6:e264. [link]
Siegal ML, Promislow DEL and Bergman A. 2007. Functional and evolutionary inference in gene networks: does topology matter? Genetica 129:83-103. [link]
Siegal ML and Bergman A. 2006. Canalization, pp. 235-251 in Evolutionary Genetics: Concepts and Case Studies, Fox CW and Wolf JB, eds. New York: Oxford University Press. [link]
Siegal ML and Baker BS. 2005. Functional conservation and divergence of intersex, a gene required for female differentiation in Drosophila melanogaster. Dev Genes Evol 215:1-12. [link]
Arbeitman MN, Fleming AA, Siegal ML, Null BH and Baker BS. 2004. A genomic analysis of Drosophila somatic sexual differentiation and its regulation. Development 131:2007-2021. [link]
Bergman A and Siegal ML. 2003. Evolutionary capacitance as a general feature of complex gene networks. Nature 424:549-552. [link] [news and views link]
Garrett-Engele CM, Siegal ML, Manoli DS, Williams BC, Li H and Baker BS. 2002. intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Development 129:4661-4675. [link]
Siegal ML and Bergman A. 2002. Waddington’s canalization revisited: developmental stability and evolution. Proc Natl Acad Sci USA 99:10528-10532. [link] [commentary link]
MarĂ­n I, Siegal ML and Baker BS. 2000. The evolution of dosage-compensation mechanisms. BioEssays 22:1106-1114. [link]
Siegal ML and Hartl DL. 2000. Application of Cre/loxP in Drosophila. Site-specific recombination and transgene coplacement. Methods Mol Biol 136:487-495. [link]
Siegal ML and Hartl DL. 1999. Oviposition-site preference in Drosophila following interspecific gene transfer of the Alcohol dehydrogenase locus. Behav Genet 29:199-204. [link]
Siegal ML and Hartl DL. 1998. An experimental test for lineage-specific position effects on alcohol dehydrogenase (Adh) genes in Drosophila. Proc Natl Acad Sci USA 95:15513-15518. [link]
Siegal ML and Hartl DL. 1996. Transgene coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila. Genetics 144:715-726. [link]
Siegal ML, Petrov DA and De Aguiar D. 1996. Triple-ligation strategy with advantages over directional cloning. BioTechniques 21:614-619. [link]