New Pending COVID Pill from Merck Has Some Safety Concern

Merck has an experimental COVID-19 pill, Molnupiravir, which utilizes a novel approach against the virus. An early study with a small sample reports that it may have an acceptable safety profile. However, the experts at the FDA share a few concerns about some of the side effects; it carries a risk of birth defects in unborn children, and the ability of the drug to change the coronavirus’ signature spike protein which allows it to enter human cells and increases the risk of new variants emerging as a result.  Those major safety concerns are prompting the FDA to seek other experts’ advice on the safety and effectiveness on it before granting approval.

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CDC Study Finds Delta Variant Increases Risk of Complications in Pregnancy

One study collected data from 1.2 million pregnancies nationwide for about a year and a half since March 2020.  It was found that premature delivery, high blood pressure and pregnancy loss is associated with COVID-19 infection during pregnancy. The rate of stillbirth has increased by 1% in unvaccinated moms infected with the virus, even more so when associated with the delta variant, with 2.7 percent pregnancies resulting in stillbirth.  Doctors are observing compromised oxygen delivery and absorption in the fetuses.  As a result, CDC is urging pregnant women to seek COVID vaccine, especially if there are underlying comorbidities and chronic illnesses.

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Pfizer’s New Pill Against Covid-19

On Nov 16, 2021, Pfizer is seeking EUA from FDA for its new pill, Paxlovid, against Covid-19.  It is going to be given together with an older antiviral drug and indicated to treat mild to moderate Covid-19.  It has shown 89% reduction in risk of hospitalization or death from Covid-19 if given with 3 days of symptom onset.  Read the full article here

Maintenance issues may be the reason behind the Champlain Towers Condo collapse in Miami

The Champlain Towers South condominium were built in 1981 in Surfside, Miami and have had repeated issues of structural damage since 1996. The most recent repairs cost more than expected and were never completed before the building collapsed in September 2021 and killing 98.  In the aftermath, the County inspected more than 500 buildings that were approaching 40-year recertification for obvious structural concerns.

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Post-traumatic stress resilience in World Trade Center survivors

A mixed-methods study utilized data from the World Trade Center Evacuation Study and recruited 29 survivors to self-report symptoms of PTSD using the PTSD checklist-civilian scale (PCL-C) and undergo semi-structured interviews. A thematic analysis identified 5 protective factors that represented resilience and 8 risk factors that influenced the likelihood of developing PTSD symptoms amongst this cohort. 

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The politicization and problematic culture within the CDC impacts its performance during the COVID-19 pandemic

The purpose of the article is to highlight the problems in the CDC from the unfolding of the pandemic, what efforts have been made in response to them, and possible next steps.

The article covers the many issues in the CDC. In general, the CDC suffers from lack of funding, authority, communication and unity. For example, although the CDC spans across the country, they lack the authority to ensure state cooperation or enforce measures, so their impact is severely limited. In addition, the CDC’s budget barely keeps up with inflation and is often too thinly distributed between states and the over ~200 different line items. The lack of funding means there is no money that can be used to prepare for events like Zika or COVID-19. Critics say this lack of resources and the poor coordination with other agencies (i.e. Department of Health and Human Services) results in an inflexible organization that cannot get much done. 

Another issue was lack of appropriate surveillance. Most  genomic surveillance labs focus on foodborne diseases, and thus had trouble adapting their tools to COVID-19. Also, the level of tracking varies widely on region, forcing CDC to use less than ideal data for very important decisions. Surveillance was further complicated by slow communication or lack thereof between health departments. As a result, some created temporary solutions such as starting new sequencing programs and encouraging collaboration with other scientists and commercial labs. These temporary solutions do not address the problems deeply rooted in the CDC’s system. The difficulty in getting departments to report serious diseases quickly and deciding what to do was first made apparent in outbreaks like the recent E. coli outbreak and the 2018 vaping outbreak. This problem was seen again in the COVID-19 pandemic when the CDC had trouble collecting, updating, tracking, and sharing data about the coronavirus, making even basic questions unknown. The CDC’s problem with data affected its advisories as well. The article focuses on the CDC’s mask guidelines, which advocated for wearing masks outside despite most experts stating that outdoor transmission was rare. The CDC also used flawed interpretation of research, which led to them stating that the risk of outdoor transmission was 10% (many times higher than other estimates), and led to them delaying their announcement that COVID-19 was airborne.

Toward the end, the article discusses possible next steps, mainly how the CDC can fix its issues. Although the CDC received an increased budget and there are efforts to reform, there is no plan to address some larger issues (i.e. leadership). The year has seen some high profile resignations, which some see as an opportunity to reform the CDC culture, while others point out that the CDC’s pride and lack of innovation are significant problems that won’t be solved that easily. The CDC receives far less funding than other agencies, which accounts for the culture and the insufficient surveillance. Therefore, the CDC’s funding system must be greatly improved so that more money is allocated to public health and money for line items can be used more flexibly. Another possible reform is giving the CDC more authority, such as forcing states to share data and enforce quarantines.

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Racial disparities among COVID-19 vaccine distribution

Communities of color, who had already suffered the most from the pandemic, had disproportionately received a smaller percentage of vaccines.  Of that, Black people’s vaccination rate is half of white counterparts, and Hispanic people even lower.

In this article, it used data from 38 states which publicly shared data on race and ethnicity for vaccinated people.  The hypothesis is that the patterns are clear across the US.

The conclusion is that people of color are vaccinated below their share in the population.  There are several reasons for it; Black and Hispanic people are less likely to have access to make online appointments, their work schedules conflict with available appointments, dependable transportation is not available, and little access to vaccine information and education.

Recognizing the disparities, states have started to address the issue by: bringing vaccines to hard-hit communities and partnering with local groups for education in multiple languages and culturally sensible. Professionals are trying to monitor if these efforts are effective in narrowing the gaps in vaccination coverage.

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