Publications

Journal Articles

  1. Battigelli, A.; Kim, J.H.; Dehigaspitiya, D.C.; Proulx, C.; Robertson, E.J.; Murray, D.J.; Rad, B.; Kirshenbaum, K.; Zuckermann, R.N. (2018) Glycosylated Peptoid Nanosheets as a Multivalent Scaffold for Protein Recognition. ACSNano. 12:2455−65 Link
  2. Kraja I.; Bing R.; Hiwatashi N.; Rousseau B.; Nalband D.; Kirshenbaum K.; Branski R.C. (2017). Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts. The Laryngoscope 127:E231–E237 Link
  3. Andreev, K.; Martynowycz, M.; Ivankin, A.; Huang, M.; Kuzmenko, I.; Meron, M.; Lin, B.; Kirshenbaum, K.; Gidalevitz, D. (2016) Cyclization Improves Membrane Permeation by Antimicrobial Peptoids. Langmuir 32(48):12905–12913. Link
  4. Wang, Y; Dehigaspitiya, D.C.; Levine, P.M.; Profit, A.A.; Haugbro, M; Imberg-Kazdan, K; Logan, S.K.; Kirshenbaum, K; Garabedian, M.J. (2016), Multivalent Peptoid Conjugates Which Overcome Enzalutamide Resistance in Prostate Cancer Cells. Cancer Res. 76(17): 5124-32. Link
  5. Craven, T.W.; Bonneau, R.; Kirshenbaum, K. (2016), PPII Helical Peptidomimetics Templated by Cation–π Interactions. ChemBioChem. 17(19): 1824-28 Link
  6. Bowling, H.; Bhattacharya, A.; Zhang, G.; Lebowitz, J. Z.; Alam, D.; Smith, P. T.; Kirshenbaum, K.; Neubert, T. A.; Vogel, C.; Chao, M. V.; Klann, E. (2016), BONLAC: A Combinatorial Proteomic Technique to Measure Stimulus-Induced Translational Profiles in Brain Slices. Neuropharmacology  100: 76-89. Link
  7. Craven, T. W.; Cho, M. K.;  Traaseth, N. J.; Bonneau, R.; Kirshenbaum, K. (2016), A Miniature Protein Stabilized by a Cation−π Interaction Network. J. Am. Chem. Soc. 138 (5): 1543-50. Link
  8. Smith, P. T.; Huang, M. L.; Kirshenbaum, K. (2015), Osmoprotective polymer additives attenuate the membrane pore-forming activity of antimicrobial peptoids. Biopolymers, 103: 227–36. Link
  9. Zhang, G.; Bowling, H.;  Hom, N.; Kirshenbaum, K.; Klann, E.; Chao, M. V.; Neubert, T. A. (2014), In-Depth Quantitative Proteomic Analysis of de Novo Protein Synthesis Induced by Brain-Derived Neurotrophic Factor. J Proteome Res., 13(12): 5707-14. Link
  10. Nalband, D. M.; Warner, B. P.; Zahler, N. H.; Kirshenbaum, K. (2014), Rapid identification of metal-binding peptoid oligomers by on-resin X-ray fluorescence screening. Biopolymers, 102: 407–415. Link
  11. Levine, P. M.; Garabedian, M. J.; Kirshenbaum, K. (2014), Targeting the Androgen Receptor with Steroid Conjugates. J. Med. Chem. 57 (20): 8224-8237. Link
  12. Butterfoss, G. L.; Drew, K.; Renfrew, P. D.; Kirshenbaum, K.; Bonneau, R. (2014) Conformational preferences of peptide–peptoid hybrid oligomers. Biopolymers , 102: 369–378.  Link
  13. Renfrew, P. D.; Craven, T. W.; Butterfoss, G. L.; Kirshenbaum, K.; Bonneau, R. (2014) A Rotamer Library to Enable Modeling and Design of Peptoid Foldamers. J. Am. Chem. Soc. 136 (24): 8772–8782. Link
  14. Konca, Y. U.; Kirshenbaum, K.; Zuckermann, R. N. (2014) Nanometer-scale siRNA carriers incorporating peptidomimetic oligomers: Physical characterization and biological activity. Int. J. Nanomedicine. 9(1): 2271—2285 Link
  15. Levine, P. M.; Craven, T. W.; Bonneau, R.; Kirshenbaum, K. (2014) Intrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine. Chem. Commun. 50: 6909-6912. Link
  16. Levine, P. M.; Craven, T. W.; Bonneau, R.; Kirshenbaum, K. (2014) Semisynthesis of Peptoid–Protein Hybrids by Chemical Ligation at Serine. Org. Lett. 16: 512–515. Link
  17. Drew, K.; Renfrew, P. D.; Craven, T. W.; Butterfoss, G. L.; Chou, F.; Lyskov, S.; Bullock, B. N.; Watkins, A.; Labonte, J. W.; Pacella, M.; Kilambi, K. P.; Leaver-Fay, A.; Kuhlman, B.; Gray, J. J.; Bradley, P.; Kirshenbaum, K.; Arora, P.S.; Das, R.; Bonneau R. (2013) Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design. PloS One. e67051. Link
  18. Levine, P. M.; Craven, T. W.; Bonneau, R.; Kirshenbaum, K. (2013) Chemoselective Fragment Condensation Between Peptide and Peptidomimetic Oligomers. Org. Biomol. Chem. 11: 4142-4146. Link
  19. Huang, M. L., Benson, M. A., Shin, S. B. Y., Torres, V. J., & Kirshenbaum, K. (2013). Amphiphilic Cyclic Peptoids That Exhibit Antimicrobial Activity by Disrupting Staphylococcus aureus Membranes. EurJOC. (17), 3560-3566. Link
  20. Vollrath, S. B. L.; Hu, C.; Brase, S.; Kirshenbaum, K. (2013) Peptoid Nanotubes: An Oligomer Macrocycle that Reversibly Sequesters Water Via Single-Crystal-to-Single-Crystal Transformations. Chem. Commun. 49: 2317-2319. Link
  21. Levine, P. M.; Carberry, T.; Holub, J. M.; Kirshenbaum, K. (2013) Crafting Precise Multivalent Architectures. Med. Chem. Commun. 4: 493-509. Link
  22. Huang, M.; Ehre, D.; Jiang, Q.; Hu, C.; Kirshenbaum, K.; Ward. M. (2012) Biomimetic Peptoid Oligomers as Dual-Action Antifreeze Agents. Proc. Natl. Acad. Sci. USA. 109, 49: 19922-19927. Link
  23. Hom, N.; Mehta, K.; Chou, T.; Foraker, A.; Brodsky, F.; Kirshenbaum, K.; Montclare, J. (2012) Anisotropic Nanocrystal Arrays Organized on Protein Lattices Formed by Recombinant Clathrin Fragments. J. Mater. Chem. 22: 23335-23339. Link
  24. Butterfoss, G. L.; Yoo, B.; Jaworski, J. N.; Chorny, I.; Dill, K. A.; Zuckermann, R.; Bonneau, R.; Kirshenbaum, K.; Voelz, V. A. (2012) De novo Structure Prediction and Experimental Characterization of Folded Peptoid Oligomers. Proc. Natl. Acad. Sci. USA. 109(36): 14320-14325. Link
  25. Levine, P. M.; Lee, E.; Greenfield, A.; Bonneau, R.; Logan, S. K.; Garabedian, M. J.; Kirshenbaum, K. (2012) Androgen Receptor Antagonism by Divalent Ethisterone Conjugates in Castrate-Resistant Prostate Cancer Cells. ACS Chem. Biol. 7: 1693-1701. Link
  26. Vollrath, S. B. L.; Brase, S.; Kirshenbaum, K. (2012) Twice Tied Tight: Enforcing Conformational Order in Bicyclic Peptoid Oligomers. Chemical Science 3: 2726-2731. Link
  27. Levine, P. M.; Imberg. K; Garabedian, M. J.; Kirshenbaum, K. (2012) Multivalent Peptidomimetic Conjugates: A Versatile Platform For Modulating Androgen Receptor Activity. J. Am. Chem. Soc. 134: 6912-6915. Link
  28. Paul, B.; Butterfoss, G. L.; Boswell, M. G.; Huang, M. L.; Bonneau, R.; Wolf, C.; Kirshenbaum, K. (2012) N-Naphthyl Peptoid Foldamers Exhibiting Atropisomerism. Org. Lett. 14: 926-929. Link
  29. Huang, M. L.; Shin, S. B. Y.; Benson, M. A.; Torres, V. J.; Kirshenbaum, K. (2012) A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents. ChemMedChem 7: 114-122. Link
  30. Jordan, P. A.; Paul, B.; Butterfoss, G. L.; Renfrew, P. D.; Bonneau, R.; Kirshenbaum, K. (2011) Oligo(N-alkoxy glycines): Trans Substantiating Peptoid Conformations. Biopolymers (Pept. Sci.) 96: 617-626. Link
  31. Paul, B.; Butterfoss, G. L.; Boswell, M. G.; Renfrew, P. D.; Yeung, F. G.; Shah, N. H.; Wolf, C.; Bonneau, R.; Kirshenbaum, K. (2011) Peptoid Atropisomers. J. Am. Chem. Soc. 133: 10910-10919. Link
  32. Pohl, N. L. B.; Kirshenbaum, K.; Yoo, B.; Schulz, N.; Zea, C. J.; Streff, J. M.; Schwarz, K. L. (2011) Student-Driven Design of Peptide Mimetics: Microwave-Assisted Synthesis of Peptoid Oligomers. J. Chem. Ed. 88: 999-1001. Link
  33. Holub, J. M.; Garabedian, M. J.; Kirshenbaum, K. (2011) Modulation of Human Estrogen Receptor α Activity by Multivalent Estradiol-Peptidomimetic Conjugates. Mol. BioSyst. 7: 337-345. Link
  34. Yoo, B.; Shin, S. B. Y.; Huang, M. L.; Kirshenbaum, K. (2010) Peptoid Macrocycles: Making the Rounds with Peptidomimetic Oligomers. Chem. Eur. J. 16: 5528-5537. Link
  35. Holub, J. M.; Kirshenbaum, K. (2010) Tricks with Clicks: Modification of Peptidomimetic Oligomers via Copper-catalyzed Azide-alkyne [3+2] Cycloaddition. Chem. Soc. Rev. 39: 1325-1337. Link
  36. Utku, Y.; Rohatgi, A.; Yoo, B.; Zuckermann, R.; Pohl, N.; Kirshenbaum, K. (2010) Rapid Multistep Synthesis of a Bioactive Peptidomimetic Oliogomer for the Undergraduate Lab. J. Chem. Ed. 87: 637-639. Link
  37. Butterfoss, G. L.; Renfrew, P. D.; Kuhlman, B.; Kirshenbaum, K.; Bonneau, R. (2009) A Preliminary Survey of the Peptoid Folding Landscape. J. Am. Chem. Soc. 131: 16798- 16807. Link
  38. Maayan, G. Ward, M.; Kirshenbaum, K. (2009) Folded Biomimetic Oligomers for Enantioselective Catalysis. Proc. Natl. Acad. Sci. USA 106: 13679-13684. Link
  39. Jagasia, R.; Holub, J. M.; Bollinger, M.; Kirshenbaum, K.; Finn, M.G. (2009) Peptide Cyclization and Cyclodimerization by CuI-Mediated Azide-Alkyne Cycloaddition. J. Org. Chem. 74: 2964-2974. Link
  40. Maayan, G.; Ward, M.; Kirshenbaum, K. (2009) Metallopeptoids. Chem. Commun. 56-58. Link
  41. Yoo, B.; Kirshenbaum, K. (2008) Peptoid Architectures: Elaboration, Actuation, and Application. Curr. Opin. Chem. Biol. 12: 714-721. Link
  42. Shah, N. H.; Butterfoss, G. L.; Nguyen, K.; Yoo, B.; Bonneau, R.; Rabenstein, D. L.; Kirshenbaum, K. (2008) Oligo(N-aryl glycines): A New Twist on Structured Peptoids. J. Am. Chem. Soc. 130: 166222-16632. Link
  43. Shah, N.H.; Kirshenbaum, K. (2008) Direct Generation of Polymer Films on Copper Surfaces Through Azide-Alkyne Cycloaddition Reactions Between Peptidomimetic Oligomers. Macromol. Rapid Commun. 29: 1134-1139. Link
  44. Shah, N.H.; Kirshenbaum, K. (2008) Photoresponsive Peptoid Oligomers Bearing Azobenzene Side Chains. Org. Biomol. Chem. 6: 2516-2521. Link
  45. Maayan, G.; Yoo, B.; Kirshenbaum, K. (2008) Heterocyclic Amines for the Construction of Peptoid Oligomers Bearing Multi-Dentate Ligands. Tet. Lett. 49: 335-338. Link
  46. Shin, S.-B.Y.; Kirshenbaum, K. (2007) Conformational Rearrangements by Water-Soluble Peptoid Foldamers. Org. Lett. 9: 5003-5006. Link
  47. Holub, J. M., Garabedian, M.J., Kirshenbaum, K. (2007) Peptoids on Steroids: Precise Multivalent Estradiol-Peptidomimetic Conjugates Generated via Azide-Alkyne [3+2] Cycloaddition Reactions. QSAR & Comb. Sci. 26: 1175-1180. Link
  48. Holub, J.M., Jang, H., Kirshenbaum, K. (2007) Fit To Be Tied: Conformation-Directed Macrocyclization of Peptoid Foldamers. Org. Lett. 9: 3275-3278. Link
  49. Shin, S.-B.Y., Yoo, B., Todaro, L., Kirshenbaum, K. (2007) Cyclic Peptoids. J. Am. Chem. Soc. 129: 3218-3225. Link
  50. Fafarman, A.T., Borbat, P.P., Freed, J.H., Kirshenbaum, K. (2007) Characterizing the structure and dynamics of folded oligomers: Pulsed ESR studies of peptoid helices. Chem. Commun. 2: 377-379. Link
  51. Utku, Y., Dehan, E., Ouerfelli, O., Piano, F., Zuckermann, R.N., Pagano, M., Kirshenbaum, K. (2006) A peptidomimetic siRNA transfection reagent for highly effective gene silencing. Mol. BioSystems. 2: 312-317. Link
  52. Spencer, T., Yoo, B., Kirshenbaum, K. (2006) Purification and modification of fullerene C60 in the undergraduate laboratory. J. Chem. Ed. 83: 1218-1220. Link
  53. Anderson, E.A., Isaacman, S., Peabody, D.S., Wang, E.Y., Canary, J.W., Kirshenbaum, K. (2006) Viral nanoparticles donning a paramagnetic coat: conjugation of MRI contrast agents to the MS2 capsid. NanoLetters. 6: 1160-1164. Link
  54. Holub, J.M., Jang, H., Kirshenbaum, K. (2006) Clickity-click: Highly functionalized peptoid oligomers generated by sequential conjugation reactions on solid-phase support. Org. Biomol. Chem. 4: 1497-1502. Link
  55. Huang, K., Wu, C.W., Sanborn, T.J., Patch, J.A., Kirshenbaum, K., Zuckermann, R.N., Barron, A.E., Radhakrishnan, I. (2006) A threaded loop conformation adopted by a family of peptoid nonamers. J. Am. Chem. Soc. 128: 1733-1738. Link
  56. Yoo, B., Kirshenbaum, K. (2005) Protease-mediated ligation of abiotic oligomers. J. Am. Chem. Soc. 127: 17132-17133. Link
  57. Jang, H.J., Fafarman, A., Holub, J.M., Kirshenbaum, K. (2005) Click to fit: Versatile polyvalent display on a peptidomimetic scaffold. Org. Let. 7: 1951-1954. Link

Book Chapters

  1. Johnson, A. ; Kirshenbaum, K.; McBride, A. E. “Designing a Sustainable and Stretchable ‘Fox Testicle’ Ice Cream”, invited chapter in The Kitchen as Laboratory; Vega, C.; Ubbink, J; van der Linden, E.; Columbia University Press, New York, 2012.
  2. Patch, J.A., Kirshenbaum, K., Seurynck, S.L., Zuckermann, R.N., Barron, A.E. “Versatile Oligo(N-substituted) Glycines: The Many Roles of Peptoids in Drug Discovery”, invited chapter in Pseudo-peptides in Drug Development; Nielsen, P.E., Ed.; Wiley-VCH, Weinheim, Germany, 2004.

News and Views

  1. Carrico, I. S.; Kirshenbaum, K. (2009) Nanoparticles: Designer Labels for Virus Coats. (News and Views) Nature Nanotech. 4:14-15. Link
  2. Kirshenbaum, K. and Arora, P. S. (2008) Cross-dressing Proteins by Olefin Metathesis. (News and Views) Nat. Chem. Biol. 4:527-528. Link
  3. Arora, P.S., Kirshenbaum, K. (2004) Nano-tailoring: Stitching alterations on viral coats. Chem. Biol. 11: 418-420. Link

Publications Prior to NYU

  1. Wu, C.W., Kirshenbaum, K., Sanborn, T.J., Patch, J.A., Huang, K., Dill, K.A., Zuckermann, R.N., Barron, A.E. (2003) Structural and spectroscopic studies of peptoid oligomers with a-chiral aliphatic side chains. J. Am. Chem. Soc. 125: 13525-13530. Link
  2. Kwon, I., Kirshenbaum, K., Tirrell, D.A. (2003) Breaking the degeneracy of the genetic code. J. Am. Chem. Soc. 125: 7512-7513. Link
  3. Kirshenbaum, K., Carrico, I.S., Tirrell, D.A. (2002) Biosynthesis of proteins incorporating a versatile set of phenylalanine analogs. ChemBioChem 3: 235-237. Link
  4. Kirshenbaum, K., Zuckermann, R.N., Dill, K.A. (1999) Designing polymers that mimic biomolecules. Curr. Opin. Struc. Biol. 9: 530-535. Link
  5. Kirshenbaum, K., Young, M., Highsmith, S. (1999) Predicting allosteric switches in myosins. Protein Sci. 8: 1806-1815. Link
  6. Young, M., Kirshenbaum, K., Dill, K.A., Highsmith, S. (1999) Predicting conformational switches in proteins. Protein Sci. 8: 1752-1764. Link
  7. Armand, P., Kirshenbaum, K., Goldsmith, R.A., Farr-Jones, S., Barron, A.E., Truong, K.T.V., Dill, K.A., Mierke, D.F., Cohen, F.E., Zuckermann, R.N., Bradley, E.K. (1998) NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains. Proc. Natl. Acad. Sci. USA 95: 4309-4314. Link
  8. Kirshenbaum, K., Barron, A.E., Goldsmith, R.A., Armand, P., Bradley, E.K., Truong, K.T.V., Dill, K.A., Cohen, F.E., Zuckermann, R.N. (1998) Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure. Proc. Natl. Acad. Sci. USA 95: 4303-4308. Link
  9. Armand, P., Kirshenbaum, K., Falicov, A., Dunbrack, R.L., Dill, K.A., Zuckermann, R.N., Cohen, F.E. (1997) Chiral N-substituted glycines can form stable helical conformations. Folding & Design 2: 369-375. Link
  10. Kirshenbaum, K., Daggett, V. (1995) Sequence effects on conformational properties of the Amyloid b(1-28) Peptide: Testing a proposed mechanism for the α→β transition. Biochemistry 34: 7640-7647. Link
  11. Kirshenbaum, K., Daggett, V. (1995) pH-Dependent conformations of the amyloid b(1-28) peptide fragment explored using molecular dynamics. Biochemistry 34: 7629-7639. Link
  12. Kirshenbaum, K., Papp, S., Highsmith, S. (1993) Cross-linking myosin subfragment 1 Cys-697 and Cys-707 modifies ATP and actin binding site interactions. Biophys. J. 65: 1121-1129. Link