Structures

Below you will find a list of currently published peptoid structures, grouped by article and to the best of our knowledge, ordered chronologically. Please see this page for a detailed explanation of our identification and other policies. We encourage researchers to use this data freely to pursue their work but we caution that our structural information has not been independently validated. In addition, our structure identifiers and nomenclature are subject to change. If you feel your findings or any work you are aware of is omitted or incorrect please alert us.

 

17AA1-6-C

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Cyclic hexamer with propargyl and methoxyethyl side chains

Tedesco, C.; Macedi, E.; Meli, A.; Pieri, G.; Della Sala, G.; Drathen, C.; Fitch, A.N.; Vaughan, G.B.M.; Izzo, I.; De Riccardis, F.

2/13/2017

X-Ray Diffraction

Synthesis, crystallization, X-ray structural
characterization and solid-state assembly of a
cyclic hexapeptoid with propargyl and
methoxyethyl side chains. (2017) Acta Cryst. B73:399-412

 

16AA1-3-A

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ω-Strand

Gorske, B.; Mumford, E.M.; Conry, R.R.

5/23/2016

X-Ray Diffraction

Tandem incorporation of enantiomeric residues engenders discrete peptoid structures. (2016) Org. Lett. 18:2780-2783

 

15AA1-6-A

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β-Peptoid Triangular Helix

Larson, J.S.; Harris, P; Fristrup, P.; Olsen, C.

5/6/2015

X-Ray Diffraction

Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds. (2015) N. Comms. 6:7013 

 

14AA1-4-C

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N-Benzyl Cyclic Tetramer

Tedesco, C.; Erra, L.; Izzo, I.; De Riccardis, F.

2/10/2014

X-Ray Diffraction

Solid state assembly of cyclic α-peptoids. (2014) Cryst. Eng. Comm. 16:3667-3687

ol-2013-01478j_0006

13AE1-4-C

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α,β-Cyclic Tetramer (N-Cα Branched Side Chain)

Caumes, C.; Fernandes, C.; Roy, O.; Hjelmgaard, T.; Wenger, E.; Didierjean, C.; Taillefumier, C.; Faure, S.
06/27/2013
X-Ray Diffraction
Cyclic α,β-Tetrapeptoids: Sequence-Dependent Cyclization and Conformational Preference. (2013) Org. Lett. 15(14): 3626–3629.

Screen Shot 2015-01-12 at 5.25.45 PM

13AD1-2-A

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Ntert-Butyl Linear Dimer

Roy, O.; Caumes, C.; Esvan, Y.; Didierjean, C.; Faure, S.; Taillefumier, C.
04/16/2013
X-Ray Diffraction
The tert-Butyl Side Chain: A Powerful Means to Lock Peptoid Amide Bonds in the Cis Conformation. (2013) Org. Lett. 15(9): 2246-2249.

nfig003

13AC4-4-A

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N-1-Naphthylethyl/N-Aryl Ribbon Tetramer

Crapster, J.; Guzei, I.; Blackwell, H.
04/09/2013
X-Ray Diffraction
A Peptoid Ribbon Secondary Structure. (2013) Angew. Chem. Int. Ed. 52: 5079.

nfig003

13AC3-3-A

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N-1-Naphthylethyl/N-Aryl Linear Trimer

Crapster, J.; Guzei, I.; Blackwell, H.
04/09/2013
X-Ray Diffraction
A Peptoid Ribbon Secondary Structure. (2013) Angew. Chem. Int. Ed. 52: 5079.

nfig003

13AC2-2-A

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N-1-Naphthylethyl/N-Aryl Linear Dimer

Crapster, J.; Guzei, I.; Blackwell, H.
04/09/2013
X-Ray Diffraction
A Peptoid Ribbon Secondary Structure. (2013) Angew. Chem. Int. Ed. 52: 5079.

nfig002

13AC1-6-A

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N-1-Naphthylethyl/N-Aryl Ribbon Hexamer

Crapster, J.; Guzei, I.; Blackwell, H.
04/09/2013
Solution NMR
A Peptoid Ribbon Secondary Structure. (2013) Angew. Chem. Int. Ed. 52: 5079.

c3cc37163h-f3

13AB1-6-C

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Cyclic Octamer Nanotube (Reversible Water Loading)

Vollrath, S.; Hu, C.; Brase, S.; Kirshenbaum, K.
02/12/2013
X-Ray Diffraction
Peptoid nanotubes: an oligomer macrocycle that reversibly sequesters water via single-crystal-to-crystal transformations. (2013) Chem. Commun. 49, 2317-2319.

ol-2012-034143_0006

13AA3-6-C

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N-Methoxyethyl Cyclic Hexamer

Izzo, I.; Ianniello, G.; De Cola, C.; Nardone, B.; Erra, L.; Vaughan, G.; Tedesco, C.; De Riccardis, F.
01/18/2013
X-Ray Diffraction
Structural Effects of Proline Substitution and Metal Binding on Hexameric Cyclic Peptoids. (2013) Org. Lett. 15(3): 598-601.

ol-2012-034143_0008

13AA2-6-C

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N-Methoxyethyl Cyclic Hexamer Sodium Complex

Izzo, I.; Ianniello, G.; De Cola, C.; Nardone, B.; Erra, L.; Vaughan, G.; Tedesco, C.; De Riccardis, F.
01/18/2013
X-Ray Diffraction
Structural Effects of Proline Substitution and Metal Binding on Hexameric Cyclic Peptoids. (2013) Org. Lett. 15(3): 598-601.

ol-2012-034143_0005

13AA1-6-C

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Proline Substituted Cyclic Hexamer Sodium Complex

Izzo, I.; Ianniello, G.; De Cola, C.; Nardone, B.; Erra, L.; Vaughan, G.; Tedesco, C.; De Riccardis, F.
01/18/2013
X-Ray Diffraction
Structural Effects of Proline Substitution and Metal Binding on Hexameric Cyclic Peptoids. (2013) Org. Lett. 15(3): 598-601.

F4.large

12AC2-9-C

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(S)-N-(1-Phenylethyl) Cyclic Nonamer

Butterfoss, G. L.; Yoo, B.; Jaworski, J. N.; Chorny, I.; Dill, K. A.; Zuckermann, R.; Bonneau, R.; Kirshenbaum, K.; Voelz, V. A.
07/12/2012
X-Ray Diffraction
De novo structure prediction and experimental characterization of folded peptoid oligomers. (2012) Proc. Natl. Acad. Sci. USA. 109(36): 14320-14325.

F2.medium

12AC1-3-A

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Phenylethyl Linear Trimer

Butterfoss, G. L.; Yoo, B.; Jaworski, J. N.; Chorny, I.; Dill, K. A.; Zuckermann, R.; Bonneau, R.; Kirshenbaum, K.; Voelz, V. A.
07/12/2012
X-Ray Diffraction
De novo structure prediction and experimental characterization of folded peptoid oligomers. (2012) Proc. Natl. Acad. Sci. USA. 109(36): 14320-14325.

c2sc20473h-f6

12AB2-16-M

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Multicyclic Hexadecamer (Doubly-Crosslinked Cyclic Octamers)

Vollrath, S. B. L.; Brase, S.; Kirshenbaum, K.
06/18/2012
X-Ray Diffraction
Twice Tied Tight: Enforcing Conformational Order in Bicyclic Peptoid Oligomers. (2012) Chemical Science 3: 2726-2731.

c2sc20473h-f4

12AB1-8-M

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Bicyclic Octamer (Two Conformers)

Vollrath, S. B. L.; Brase, S.; Kirshenbaum, K.
06/18/2012
X-Ray Diffraction
Twice Tied Tight: Enforcing Conformational Order in Bicyclic Peptoid Oligomers. (2012) Chemical Science 3: 2726-2731.

ol-2011-03452f_0008

12AA2-6-C

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N-Aryl/N-Alkyl Cyclic Hexamer Atropisomer

Paul, B.; Butterfoss, G.; Boswell, G.; Huang, M.; Bonneau, R.; Wolf, C.; Kirshenbaum, K.
01/24/2012
X-Ray Diffraction
N-Napthyl Peptoid Foldamers Exhibiting Atropisomerism. (2012) Org. Lett. 14: 926-929.

ol-2011-03452f_0007

12AA1-2-A

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N-Aryl/N-Alkyl Linear Dimer Atropisomer

Paul, B.; Butterfoss, G.; Boswell, G.; Huang, M.; Bonneau, R.; Wolf, C.; Kirshenbaum, K.
01/24/2012
X-Ray Diffraction
N-Napthyl Peptoid Foldamers Exhibiting Atropisomerism. (2012) Org. Lett. 14: 926-929.

ja-2011-04755p_0004

11AD3-4-A

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N-1-Naphthylethyl Helical Tetramer

Stringer, J. R.; Crapster, J. A.; Guzei, I. A.; Blackwell, H. E.
08/24/2011
X-Ray Diffraction
Extrordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of α-Chiral Aromatic N-1-Naphthylethyl Side Chains. (2011) J. Am. Chem. Soc. 133: 15559-15567.

ja-2011-04755p_0004

11AD2-3-A

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N-1-Naphthylethyl Linear Trimer

Stringer, J. R.; Crapster, J. A.; Guzei, I. A.; Blackwell, H. E.
08/24/2011
X-Ray Diffraction
Extrordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of α-Chiral Aromatic N-1-Naphthylethyl Side Chains. (2011) J. Am. Chem. Soc. 133: 15559-15567.

ja-2011-04755p_0004

11AD1-2-A

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N-1-Naphthylethyl Linear Dimer

Stringer, J. R.; Crapster, J. A.; Guzei, I. A.; Blackwell, H. E.
08/24/2011
X-Ray Diffraction
Extrordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of α-Chiral Aromatic N-1-Naphthylethyl Side Chains. (2011) J. Am. Chem. Soc. 133: 15559-15567.

untitled

11AC3-3-A

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N-Aryl Linear Trimer Enanotiomeric Pair

Paul, B.; Butterfoss, G. L.; Boswell, M. G.; Renfrew, P. D.; Yeung, F. G.; Shah, N. H.; Wolf, C.; Bonneau, R.; Kirshenbaum, K.
06/02/2011
X-Ray Diffraction
Peptoid Atropisomers. (2011) J. Am. Chem. Soc. 133: 10910-10919.

Screen Shot 2015-01-06 at 3.31.30 PM

11AC2-2-A

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N-Aryl Linear Dimer Atropisomers

Paul, B.; Butterfoss, G. L.; Boswell, M. G.; Renfrew, P. D.; Yeung, F. G.; Shah, N. H.; Wolf, C.; Bonneau, R.; Kirshenbaum, K.
06/02/2011
X-Ray Diffraction
Peptoid Atropisomers. (2011) J. Am. Chem. Soc. 133: 10910-10919.

Screen Shot 2015-01-06 at 3.29.36 PM

11AC1-2-A

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N-Aryl Linear Dimer Atropisomers

Paul, B.; Butterfoss, G. L.; Boswell, M. G.; Renfrew, P. D.; Yeung, F. G.; Shah, N. H.; Wolf, C.; Bonneau, R.; Kirshenbaum, K.
06/02/2011
X-Ray Diffraction
Peptoid Atropisomers. (2011) J. Am. Chem. Soc. 133: 10910-10919.

726_2011_887_Fig2_HTML

11AB1-8-C

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Cyclic α,β-Peptoid Octamer

De Santis, E.; Hjelmgaard, T.; Faure, S.; Roy, O.; Didierjean, C.; Alexander, B. D.; Siligardi, G.; Hussain, R.; Javorfi, T.; Edwards, A. A.; Taillefumier, C.
04/02/2011
X-Ray Diffraction
Cyclic α,β-peptoid octamers with differing side chain patterns: synthesis and conformational investigation. (2011) Amino Acids. 41: 663-672.

nfig009

11AA2-3-A

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N-Hydroxy Amide Linear Trimer

Crapster, J. A.; Stringer, J. R.; Guzei, I. A.; Blackwell, H. E.
02/03/2011
X-Ray Diffraction
Design and Conformational Analysis of Peptoids Containing N-Hydroxy Amides Reveals a Unique Sheet-Like Secondary Structure. (2011) Biopolymers. 96: 604-616.

nfig007

11AA1-2-A

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N-Hydroxy Amide Linear Dimer

Crapster, J. A.; Stringer, J. R.; Guzei, I. A.; Blackwell, H. E.
02/03/2011
X-Ray Diffraction
Design and Conformational Analysis of Peptoids Containing N-Hydroxy Amides Reveals a Unique Sheet-Like Secondary Structure. (2011) Biopolymers. 96: 604-616.

untitled

10AA1-3-A

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ortho-Substituted N-Aryl Linear Trimer

Stringer, J. R.; Crapster, J. A.; Guzei, I. A.; Blackwell, H. E.
08/19/2010
X-Ray Diffraction
Construction of Peptoids with All Trans-Amide Backbones and Peptoid Reverse Turns via the Tactical Incorporation of N-Aryl Side Chains Capable of Hydrogen Bonding. (2010) J. Org. Chem. 75: 6068-6078.

untitled

08AC2-2-A

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N-Aryl Linear Dimer

Shah, N.; Butterfoss, G.; Nguyen, K.; Yoo, B.; Bonneau, R.; Rabenstein, D.; Kirshenbaum, K.
11/17/2008
X-Ray Diffraction
Oligo(N-aryl glycines): A New Twist on Structured Peptoids. (2008) J. Am. Chem. Soc. 130: 16622-16632.

untitled

08AC1-6-C

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N-Aryl/N-Alkyl Cyclic Hexamer

Shah, N.; Butterfoss, G.; Nguyen, K.; Yoo, B.; Bonneau, R.; Rabenstein, D.; Kirshenbaum, K.
11/17/2008
X-Ray Diffraction
Oligo(N-aryl glycines): A New Twist on Structured Peptoids. (2008) J. Am. Chem. Soc. 130: 16622-16632.

b806508j-f2

08AB2-4-C

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N-Benzyloxyethyl Cyclic Tetramer

Maulucci, N.; Izzo, I.; Bifulco, G.; Aliberti, A.; De Cola, C.; Comegna, D.; Gaeta, C.; Napolitano, A.; Pizza, C.; Tedesco, C.; Flot, D.; De Riccardis, F.
07/03/2008
X-Ray Diffraction
Synthesis, structures, and properties of nine-, twelve-, and eighteen- membered N-benzyloxyethyl cyclic α-peptoids. (2008) Chem. Comm. 33: 3927-3929.

b806508j-f7

08AB1-6-C

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N-Benzyloxyethyl Cyclic Hexamer Strontium Picrate Complex

Maulucci, N.; Izzo, I.; Bifulco, G.; Aliberti, A.; De Cola, C.; Comegna, D.; Gaeta, C.; Napolitano, A.; Pizza, C.; Tedesco, C.; Flot, D.; De Riccardis, F.
07/03/2008
X-Ray Diffraction
Synthesis, structures, and properties of nine-, twelve-, and eighteen- membered N-benzyloxyethyl cyclic α-peptoids. (2008) Chem. Comm. 33: 3927-3929.

untitled

08AA1-4-C

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Cyclic β-Peptoid Tetramer (propargyl side chains)

Roy, O.; Faure, S.; Thery, V.; Didierjean, C.; Taillefumier, C.
02/06/2008
X-Ray Diffraction
Cyclic β-Peptoids. (2008) Org. Lett. 10: 921-924.

Microsoft Word - ja066960o-3_word2000.doc

07AA2-8-C

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N-Alkyl Cyclic Octamer

Shin, S.; Yoo, B.; Todaro, L. J.; Kirshenbaum, K.
02/27/2007
X-Ray Diffraction
Cyclic Peptoids. (2007) J. Am. Chem. Soc. 129: 3218-3225.

Microsoft Word - ja066960o-3_word2000.doc

07AA1-6-C

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N-Alkyl Cyclic Hexamer

Shin, S.; Yoo, B.; Todaro, L. J.; Kirshenbaum, K.
02/27/2007
X-Ray Diffraction
Cyclic Peptoids. (2007) J. Am. Chem. Soc. 129: 3218-3225.

untitled

06AA1-9-A

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Threaded Loop Nonamer (α-chiral aromatic side chains)

Huang, K., Wu, C.W., Sanborn, T.J., Patch, J.A., Kirshenbaum, K., Zuckermann, R.N., Barron, A.E., Radhakrishnan, I.
01/14/2006
Solution NMR
A threaded loop conformation adopted by a family of peptoid nonamers. (2006) J. Am. Chem. Soc. 128: 1733-1738.

ja037540rf00001

03AA1-5-A

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Polyproline Type I-Like Pentamer (α-chiral aliphatic side chains)

Wu, C.W.; Kirshenbaum, K.; Sanborn, T.J.; Patch, J.A.; Huang, K.; Dill, K.A.; Zuckermann, R.N.; Barron, A.E.
10/11/2003
X-Ray Diffraction
Structural and spectroscopic studies of peptoid oligomers with a-chiral aliphatic side chains. (2003) J. Am. Chem. Soc. 125: 13525-13530.