Kirshenbaum Research Lab – NYU Chemistry

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Synthesis

Peptoid-Protein Hybrids
Peptoid-Protein Hybrids

Chemical ligation protocols were explored for generating semisynthetic peptoid–protein hybrid architectures containing a native serine residue at the ligation site. Peptoid oligo...

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Bioarchitectures

Multivalent Architectures
Multivalent Architectures

Multivalency is a powerful strategy in molecular pharmacology that can establish high-affinity binding between multiple conjoined ligands and corresponding biomolecular targets. Re...

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Biomedicine

Antimicrobial Peptoid Membrane Pore-Forming Activity
Antimicrobial Peptoid Membrane Pore-Forming Activity

Antimicrobial peptides (AMPs) are critical components of the innate immune system and exhibit bactericidal activity against a broad spectrum of bacteria. We investigated the use of...

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Materials

Metal-Binding Peptoids and X-Ray Fluorescence
Metal-Binding Peptoids and X-Ray Fluorescence

N-Substituted glycine peptoid oligomers have recently attracted attention for their metal binding capabilities. Due to their efficient synthesis on solid phase, peptoids are well s...

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Design

Peptide-Peptoid Hybrids Conformations
Peptide-Peptoid Hybrids Conformations

Peptomers are oligomeric molecules composed of both α-amino acids and N-substituted glycine monomers, thus creating a hybrid of peptide and peptoid units. Peptomers have been used...

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