Pathogenesis of Obstruction/Emphysema and the Microbiome (POEM) in HIV
- Alison Morris, University of Pittsburgh School of Medicine
- Elodie Ghedin, NYU
NIH/NHLBI U01 HL098962
This study will help us determine which infections are present in the lungs of people with HIV and how the infections might explain why HIV-infected individuals develop emphysema
Sarcoidosis and AAT genomics and informatics center (SAGIC)
- Naftali Kaminski, Yale U. (PI)
The objectives of the SAGIC will be addressed through two research projects. Project 1: A1AT microbiome – will address the hypothesis that shifts in the lung microbiome determine the extent of lung involvement in A1AT and that they are reflected in mRNA and microRNA changes in surrogate tissues, and Project 2: Novel molecular phenotypes in Sarcoidosis – will address the hypothesis that systemic inflammation as reflected in gene expression changes in PBMC is indicative of disease extent, microbiome shifts and granuloma molecular networks.