The Molecular Devices FlexStation 3 multi-mode microplate reader has a dual optical systems operating above and below the microplates, measuring absorbance, fluorescence intensity, fluorescence polarization, luminescence, and time-resolved fluorescence (5 detection modes). This compact benchtop system integrates multi-mode microplate optics with precision, programmable liquid handling for perfectly timed, automated biochemical and cell-based assays. Using an 8- or 16-channel pipettor, the FlexStation 3 reader offers added assay flexibility over dispenser-based systems by transferring reagents from 96 or 384 distinct wells in a source plate to a read plate simultaneously. In addition, users can define individual reagents and concentrations to be delivered to each well.