Author: Daniela Buccella

Impaired cellular magnesium transport in Non-Alcoholic Liver Disease

Magnesium_Liver_CNNM

Our study on cellular magnesium imbalance in liver disease is now in press (doi:10.1016/j.jhep.2021.01.043) in the Journal of Hepatology!

Patients with liver disease were found to have significantly elevated expression of Cyclin M4 (CNNM4), a protein that modulates cellular magnesium levels. The protein presents a potential therapeutic target for non-alcoholic steatohepatitis, a form of fatty liver disease characterized by inflammation and liver fibrosis. Non-alcoholic fatty liver disease affects billions of people worldwide and is associated with obesity and other comorbidities. The study underscores the importance of magnesium balance for supporting liver health and provides insight into how this essential metal affects lipid metabolism at the cellular level.

The research was conducted by an international team of scientists from the Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), CIBEREHD, University of the Basque Country, NYU, Silence Therapeutics, CABIMER, Universidad Pablo de Olavide, CIBERDEM, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, and University Hospital Marqués de Valdecilla/IDIVAL.

Congratulations to lab alumni Dr. Jessica Gruskos and Kevan Chu!

Check out the Highlight in NYU research news

Celebrating the International Year of the Periodic Table

The New York Local Section of the American Chemical Society celebrated the International Year of the Periodic Table (IYPT 2019) with a giant 3D Periodic Table display at the New York Hall of Science. The display was unveiled on October 18, 2019, to kickoff events of the National Chemistry Week and commemorate the 150th Anniversary of Mendeleev’s Periodic Table. 

The Buccella group contributed an entry to the educational display, highlighting one of our favorite elements: Zinc!

Read more about the events of the IYPT 2019 at the NYACS.