This talk will focus on a “design-build-test” automated workflow for the creation of low cost, continuous flow, CNC milled microfluidics. This includes a specification process to describe the relationship between the flow of liquid on the chip and its associated control. This description then proceeds through a design automation process with many similarities to those present in the design of semiconductor-based electronics. The end result is a set of design files to create and control the microfluidic using off the shelf manufacturing and control hardware. I will also discuss how security concerns related to the fabrication and operation of the device can be integrated in the automated, software-based design of microfluidics.