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We are a bioorganic chemistry group in the Department of Chemistry at New York University.  Research in our lab utilizes expertise in organic chemistry to develop synthetic inhibitors of protein-protein and protein-nucleic acids interactions, and catalysts for peptide and protein synthesis.

Protein-protein and protein-nucleic acids interactions are attractive targets for the discovery of new therapeutics but discovery of synthetic ligands that inhibit these complexes remains a challenge. Proteins often utilize small folded domains for recognition of other biomolecules.  The hypothesis guiding our research is that by mimicking these folded domains we can modulate the function of a particular protein with metabolically stable synthetic molecules.  Please visit the Research and Publications pages for more details.