We are using DREADDs to interrogate the role of specific brain pathways in the maladaptive behaviors elicited in activity-based anorexia

Chen, Y.-W., Actor-Engel, H., & Aoki, C. (2018). ⍺4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males. Molecular and Cellular Neuroscience. doi:10.1016/j.mcn.2018.04.008

 

 

Chen, Y.-W., Akad, A., Aderogba, R., Chowdhury, T.G., & Aoki, C. (2018). Dendrites of the dorsal and ventral hippocampal CA1 pyramidal neurons of singly housed female rats exhibit lamina-specific growths and retractions during adolescence that are responsive to pair housing. Synapse. 
e22034.doi:10.1002/syn.22034.

 

 

 

 

 

Aoki, C., Chen, Y.-W., Chowdhury, T.G., Piper, W. (2017) α4βδ-GABAA receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at excitatory synapses.  Journal of Neuroscience Research. doi: 10.1002/jnr.24035

 

 

 

 

figure-5
Chen, Y.-W., Actor-Engel, H., Sherpa, A. D., Klingensmith., L., Chowdhury, T.G., & Aoki, C. NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. (2016) Brain Structure and Function. doi: 10.1007/s00429-016-1341-7. 

 

 

 

 

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Chen, Y.-W., Surgent, O., Rana, B. S., Lee, F., & Aoki, C. (2016). Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia. Cerebral Cortex. doi: 10.1093/cercor/bhw210

 

 

 

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Chen, Y.-W., Wable, G. S., Chowdhury, T. G., & Aoki, C. (2016). Enlargement of Axo-Somatic Contacts Formed by GAD-Immunoreactive Axon Terminals onto Layer V Pyramidal Neurons in the Medial Prefrontal Cortex of Adolescent Female Mice Is Associated with Suppression of Food Restriction-Evoked Hyperactivity and Resilience to Activity-Based Anorexia. Cerebral Cortex. doi: 10.1093/cercor/bhv087

 

 

 

 

 

 

aoki-fig-1-si-on-adolescence-copy

fig-7-summary-with-red-neuron-copy-1Aoki, C., Chowdhury, T. G., Wable, G. S., Chen, Y.-W. (2016). Synaptic changes in the hippocampus of adolescent female rodents associated with resilience to anxiety and suppression of food restriction-evoked hyperactivity in an animal model for anorexia nervosa. Brain Research. doi: 10.1016/j.brainres.2016.01.019