Aoki Lab

Theresa S. Rimmele , Shaomin Li, Jens Velde Andersen, Emil W. Westi, Alexander Rotenberg, Jianlin Wang, Blanca Irene Aldana, Dennis J. Selkoe, Chiye J. Aoki, Chris G. Dulla, Paul Allen Rosenberg. (2021) Neuronal loss of the glutamate transporter GLT-1 promotes excitotoxic injury of the hippocampus . Front. Cell. Neurosci. 15:788262. doi: 10.3389/fncel.2021.788262 PDF

 

Chowdhury, T. G., Fenton, A. A., Aoki, C. (2020) Effects of adolescent experience of food restriction and exercise on spatial learning and open field exploration of female rats.  Hippocampus. 31(2):  170-188. PDF  DOI: 10.1002/hipo.23275

Barbara Scolnick, Beth Zupec-Kania, Lori Calabrese, Chiye Aoki and Thomas Hildebrandt. (2020) Remission from chronic anorexia nervosa with ketogenic diet and ketamine: Case report.  Frontiers in Psychiatry 30 Jul 2020.  PDF     doi: 10.3389/fp

Olesia Bilash, Yi-Wen Chen, Ang Sherpa, Chiye Aoki (2020) Suppression of food restriction-evoked hyperactivity in activity-based anorexia animal model through glutamate transporters GLT-1 at excitatory synapses in the hippocampus, Synapse Volume 75 (7) July 2021, e22197. PDF doi.org/10.1002/syn.22197

Tara Chowdhury, Andre Fenton, Chiye Aoki (2020) Effects of adolescent experience of food restriction and exercise on spatial learning and open field exploration of female rats. Hippocampus, Volume31, Issue2, February 2021, Pages 170-188  PDF http://dx.doi.org/10.1002/hipo.23275 

Chiye Aoki (2020) Activity-Based Anorexia, an Animal Model of Anorexia Nervosa for Investigating Brain Plasticity Underlying the Gain of Resilience. In: Animal Models of Eating Disorders, 2nd edition (Neuromethods  v.161), Chapter 15, pp 267-296. Nicole M. Avena, Editor, Wolfgang Walz, Series Editor, Humana Press. PDF  Chapter 15 only

Luye Qin, Hanna S. Actor-Engel, Moon-Sook Woo, Yi-Wen Chen, Sunghee Cho*, Chiye Aoki* (2019) An increase of excitatory-to-inhibitory synaptic balance in the contralateral cortico-striatal pathway underlies improved stroke recovery in BDNF Val66Met SNP mice. Neurorehabilitation and Neural Repair, Jul 30 2019.  PDF    NIHMS1537003 DOI: 10.1177/1545968319872997

Laura F. McNair ,Jens V. Andersen, Jakob D. Nissen, Yan Sun, Kathryn D. Fischer, Nathaniel W. Hodgson, Muzi Du, Chiye J. Aoki, Helle S. Waagepetersen, Paul A. Rosenberg, Blanca I. Aldana. (2020) Conditional knockout of GLT-1 in neurons leads to alterations in aspartate homeostasis and synaptic mitochondrial metabolism in striatum and hippocampus Accepted Feb 25, 2020 in Neurochemical Research, Special Issue. (NERE-D-19-00653R1) PDF

Ang D Sherpa, David N Guifoyle, Aditi A Naik, Jasmina Isakovic*, Fumitoshi Irie, Yu Yamaguchi, Jan Hrabe, Chiye Aoki, Sabina Hrabetova. (2019)  Integrity of white matter is compromised in mice with hyaluronan deficiency.  Neurochemical Research. Special Issue edited by C. Nicholson, in honor of Prof. Eva Sykova. 45(1):53-67. PDF  doi: 10.1007/s11064-019-02819-z. PMCID: PMC6898766

McNair, Laura,  Andersen, Jens, Aldana, Blanca, Hohnholt, Michaela,  Nissen, Jakob, Sun,Yan, Fischer Kathryn, Sonnewald, Ursula, Nyberg, Nils, Webster, Sophie,  Kapur,  Kush, Rimmele, Teresa, Barone, Ilaria, Hawks-Mayer, Hannah,  Lipton, Jonathan, Hodgson, Nathaniel, Aoki, Chiye, Rosenberg, Paul, and Waagepetersen, Helle (2019)  Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function. J. Neurosci. 39(25) 4847-63.  PDF  DOI: https://doi.org/10.1523/JNEUROSCI.0894-18.2019

Chowdhury, Tara G., Wable, Gauri S., Chen,Yi-Wen, Tateyama,Kei,  Yu, Irene,  Wang, Jia-Yi , Reyes, Alex D. and Aoki, Chiye. (2018) Voluntary wheel running exercise evoked by food-restriction stress exacerbates weight loss of adolescent female rats but also promotes resilience by enhancing GABAergic inhibition of pyramidal neurons in the dorsal hippocampus. Cerebral Cortex, 29(10):4035-4049.  PDF  doi: 10.1093/cercor/bhy283. PMCID:PMC6931273

Chen,Yi-Wen, Sherpa, Ang D. and C Aoki. (2018) Single injection of ketamine during mid-adolescence promotes long-lasting resilience to activity-based anorexia in female mice by increasing food intake and attenuating hyperactivity as well as anxiety-like behavior. International J of Eating Disorders, 51(7354) July 16, 2018.  PDF DOI: 10.1002/eat.22937  PMID: 30102796

C. Aoki (2016) The neurobiological roots of individuality and anxiety. Scientia Global. 2016 Oct 3:107:18-22 PDF

Santiago, Adrienne, Lim, Kayla Y., Opendak, Maya, Sullivan, Regina, Chiye Aoki. (2018) Early life trauma increases threat response of peri-weaning rats, reduction of axo-somatic synapses formed by PV cells and perineuronal net in the basolateral nucleus of amygdala. J Comparative Neurol. 526(16):2647-2664.  PDF  https://doi.org/10.1002/cne.24522cne.24522   PMCID:PMC6319912

Chen, Y.-W., Actor-Engel, H., & Aoki, C. (2018). ⍺4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males.  Molecular and Cellular Neuroscience 90: 33-48.    PDF doi:10.1016/j.mcn.2018.04.008

Chen, Y.-W., Akad, A., Aderogba, R., Chowdhury, T.G., & Aoki, C. (2018). Dendrites of the dorsal and ventral hippocampal CA1 pyramidal neurons of singly housed female rats exhibit lamina-specific growths and retractions during adolescence that are responsive to pair housing. Synapse. e22034. PDF doi:10.1002/syn.22034.

Aoki, C., & Sherpa, A. D. (2017). Making of a Synapse: Recurrent Roles of Drebrin A at Excitatory Synapses Throughout Life. In T. Shirao & Y. Sekino (Eds.), Drebrin: From Structure and Function to Physiological and Pathological Roles, Springer Japan, Tokyo, pp. 119-139. PDF PDF

Santiago, A., Aoki, C., & Sullivan, R. M. (2017). From attachment to independence: Stress hormone control of ecologically relevant emergence of infants’ responses to threat. Curr Opin Behav Sci, 14: 78-85. PDF doi:10.1016/j.cobeha.2016.12.010

Aoki, C., Chen, Y.-W., Chowdhury, T.G., Piper, W. (2017) α4βδ-GABA_A receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at excitatory synapses.  Journal of Neuroscience Research. doi: 10.1002/jnr.24035 PDF

Chen, Y.-W., Actor-Engel, H., Sherpa, A. D., Klingensmith., L., Chowdhury, T.G., & Aoki, C. (2017) NR2A- and NR2B-NMDA receptors and drebrin within postsynaptic spines of the hippocampus correlate with hunger-evoked exercise. Brain Structure and Function. 222 (5), 2271-2294. doi: 10.1007/s00429-016-1341-7. PDF

Sherpa, A. D., Aoki, C., & Hrabetova, S. (2016) Noradrenaline drives structural changes in astrocytes and brain extracellular space.  Chapter in book Noradrenergic Signaling and Astroglia, Elsevier, PDF

Sherpa, A. D., Xiao, F.,  Joseph, N., Aoki, C., & Hrabetova., S. (2016) Activation of beta-adrenergic receptors in rat visual cortex expands astrocytic processes and reduces extracellular space volume. Synapse, 70 (8): 307-316. doi: 10.1002/syn.21908 (graphic summary featured as the issue’s cover art).PDF

Chen, Y.-W., Surgent, O., Rana, B. S., Lee, F., & Aoki, C. (2017). Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia. Cerebral Cortex. 27 (8): 3980-3993. doi: 10.1093/cercor/bhw210 PDF

Nedelescu, H., Chowdhury, T. G., Wable, G. S., Arbuthnott, G., & Aoki., C.  (2016) Cerebellar sub-divisions differ in exercise-induced plasticity of noradrenergic axons and in their association with resilience to activity-based anorexia. Brain Structure and Function, doi: 10.1007/s00429-016-1220-2 PDF

Mitre, M., Marlin, B. J., Schiavo, J. K., Morina, E., Norden, S. E., Hackett, T. A., Aoki C. J., Chao M. V., & Froemke, R. C. (2016). A Distributed Network for Social Cognition Enriched for Oxytocin Receptors. Journal of Neuroscience, 36(8): 2517-2535. PDF

Shen H., Sabaliauskas N., Yang L., Aoki C., & Smith S. (2017). Role of α4-containing GABAA receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period. Brain Research, 1654: 116-122. doi: 10.1016/j.brainres.2016.01.020 PDF

Aoki, C., Chowdhury, T. G., Wable, G. S., Chen, Y.-W. (2017). Synaptic changes in the hippocampus of adolescent female rodents associated with resilience to anxiety and suppression of food restriction-evoked hyperactivity in an animal model for anorexia nervosa. Brain Research, 1654: 102-115. doi: 10.1016/j.brainres.2016.01.019 PDF

Chowdhury, T. G., Chen, Y.-W., & Aoki, C. (2015). Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa. Journal of Visualized Experiments : JoVE, (104): 52927. Advance online publication. http://doi.org/10.3791/52927 PDF

Wable, G. S., Chen, Y.-W., Rashid, S., & Aoki, C. (2015). Exogenous progesterone exacerbates running response of adolescent female mice to repeated food restriction stress by changing α4-GABAA receptor activity of hippocampal pyramidal cells. Neuroscience, 310: 322-341. PDF

Chen, Y.-W., Wable, G. S., Chowdhury, T. G., & Aoki, C. (2016). Enlargement of Axo-Somatic Contacts Formed by GAD-Immunoreactive Axon Terminals onto Layer V Pyramidal Neurons in the Medial Prefrontal Cortex of Adolescent Female Mice Is Associated with Suppression of Food Restriction-Evoked Hyperactivity and Resilience to Activity-Based Anorexia. Cerebral Cortex. 26(6): 2574-2589. doi: 10.1093/cercor/bhv087. Epub, 2015, May 15. PDF

Petr, G. T., Sun, Y., Frederick, N. M., Zhou, Y., Dhamne, S. C., Hameed, M. Q., Miranda C, Bedoya E. A., Fischer K.D., Armsen W, Wang J, Danbolt N.C., Rotenberg A, Aoki C. J., Rosenberg P. A. (2015). Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes. Journal of Neuroscience, 35(13): 5187-5201. PDF

Wable G. S., Min J. Y., Chen Y.-W. and Aoki C. (2015). Anxiety is correlated with running in adolescent female mice undergoing activity-based anorexia. Behavioral Neuroscience, 129 (2): 170 –182. PDF

Chowdhury T. G., Rios M. B., Chan T. E., Cassataro D. S., Barbarich-Marsteller N. C., Aoki C. (2014). Activity-based anorexia during adolescence disrupts normal development of the CA1 pyramidal cells in the ventral hippocampus of female rats. Hippocampus 24(12): 1421-9. doi:10.1002/hipo.22320. PDF

Chowdhury T. G., Barbarich-Marsteller N., Chan T. E. and Aoki, C. (2014). Activity-based anorexia has differential effects on apical dendritic branching in dorsal and ventral hippocampal CA1. Brain Structure and Function, 219: 1935-1945.doi: 10.1007/s00429-013-0612-9 PDF

Aoki C., Wable G., Chowdhury T. G., Sabaliauskas N. A., Laurino K., Barbarich-Marsteller N. C. (2014). α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia. Neuroscience, 265: 108-23. doi: 10.1016/j.neuroscience.2014.01.011 PDF

Wable G. S., Barbarich-Marsteller N. C., Chowdhury T. G., Sabaliauskas N. A., Farb C., Aoki C. (2014). Excitatory synapses on dendritic shafts of the caudal basal amygdala exhibit elevated levels of GABAA receptor α4 subunits following the induction of activity-based anorexia. Synapse, 68(1):1-15. PDF

Chowdhury T. G., Wable G. S., Sabaliauskas N. A. and Aoki C. (2013). Adolescent female C57BL/6 mice with vulnerability to activity based anorexia exhibit weak inhibitory input onto hippocampal CA1 pyramidal cells. Neuroscience, 241:250-67. doi: 10.1016/j.neuroscience.2013.03.020 PDF

Aoki C., Sabaliauskas N., Chowdhury T., Min J. Y., Colacina A. R., Laurino K. and Barbarich-Marsteller N. C. (2011). Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABAA receptor α4 and delta subunits at the plasma membrane of hippocampal CA1 spines. Synapse, 66 (5): 391-407. PMCID: PMC3292704. doi: 10.1002/syn.21528. PMID:22213233 PDF

Nedelescu H., Kelso C.,Lazaro-Munoz G., Purpura M., Cain C.K., LeDoux J. E., Aoki C. (2010). Endogenous GluR1-containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: an electron microscopic immunocytochemical study. J Comp Neurol, 518 (23): 4723-39. PDF

Shen H., Sabaliauskas N., Sherpa A., Fenton A. A., Stelzer, A, Aoki C., and Smith S. S. (2010). A Critical Role for α4-Beta-Delta GABAA Receptors in Shaping Learning Deficits at Puberty in Mice.  PDF   Science, 327: 1515-1518

C. Aoki, Nobuhiko Kojima, Nicole Sabaliauskas, Lokesh Shah, Tunazzina H. Ahmed, John Oakford, Tahir Ahmed, Hiroyuki Yamazaki, Kenji Hanamura and Tomoaki Shirao (2009) Drebrin A knockout eliminates the rapid form of homeostatic synaptic plasticity at excitatory synapses of intact adult cerebral cortex.  J. Comp Neurol 517: 105-121. PDF

Smith S., Aoki C., and Shen H. (2009). Puberty, Steroids and the GABAA receptor. Psychoneuroendocrinology, 345:S91-S103. PDF

Levy R. B., Reyes A. D., and Aoki C. (2008). Cholinergic modulation of local pyramid-interneuron synapses exhibiting divergent short-term dynamics in rat sensory cortex. Brain Research, 1215: 97-104. doi:10.1016/j.brainres.2008.03.067  PDF 

Sarro E. C., Kotak V. C., Sanes D. H., and Aoki C. (2008). Hearing loss alters the subcellular distribution of presynaptic GAD and postsynaptic GABAA receptors in the auditory cortex. Cerebral Cortex, 18: 2855-67. doi: 10.1093/cercor/bhn044 PDF

Disney A. and Aoki C. (2008). Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin-immunoreactive neurons. J Comp Neurol, 507: 1748-1762. doi: 10.1002/cne.21616 PDF

Disney A.,  Aoki C., and Hawken M. J. (2007). Gain modulation by nicotine in Macaque V1. Neuron 56: 701-713. doi: 10.1016/j.neuron.2007.09.034 PDF

Shen H., Gong Q. H., Aoki C., Yuan M., Ruderman Y., Dattilo M., Williams K., Smith S. S. (2007). Reversal of neurosteroid effects at alpha4beta2delta GABA(A) receptors triggers anxiety at puberty. Nat Neurosci., 10: 469-77. doi:10.1038/nn1868

Aoki C., Mahadomrongkul V., Fujisawa S., Habersat R. and Shirao T. (2007). Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer’s disease pathology in double knock-in mice. J Comp. Neurol., 505: 352-362. doi: 10.1002/cne.21485 PDF

Taniguchi H., Gollan L., Scholl F. G., Mahadomrongkul V., Dobler E., Limthong N., Peck M., Aoki C., and Scheiffele P. (2007). Silencing of neuroligin function by postsynaptic neurexins. J Neurosci., 27: 2815-24. doi: 10.1523/JNEUROSCI.0032-07.2007

Fujisawa S., Shirao T., and Aoki C. (2006). In vivo, competitive blockade of NMDA receptors induces changes in F-actin and drebrin A distributions within dendritic spines of adult rat cortex. Neuroscience, 140(4):1177-87. doi: 10.1016/j.neuroscience.2006.03.009 PDF 

Levy R., Reyes A., and Aoki C. (2006). Nicotinic and muscarinic reduction of unitary excitatory postsynaptic potentials in sensory cortex; dual intracellular recording. J Neurophysiol., 95(4):2155-66.

Chang E. H., Savage M. J., Flood D. G., Thomas J. M., Levy R. B., Mahadomrongkul V., Shirao T., Aoki C., and Huerta P. T. (2005). AMPA receptor downscaling at the onset of Alzheimer’s pathology in double knock-in mice. Proc Natl Acad Sci., 103:3410-3415

Aoki C., Sekino Y., Hanamura K., Mahadomrongkul V., Fujisawa S., Ren Y. and Shirao T. (2005). Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses. J Comp Neurol., 483:383-402 cne.20449

Chen W., Mahadomrongkul V., Berger U. V., Bassan M., DeSilva T., Tanaka K., Irwin N., Aoki C., and Rosenberg P. A. (2004). The Glutamate Transporter GLT1a is Expressed in Excitatory Axon Terminals of Mature Hippocampal Neurons. J Neurosci, 24: 1136-48.

C Aoki, S Fujisawa, V Mahadomrongkul, PJ Shah*, K Nader and A Erisir. (2003) NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines, postsynaptic densities and axon terminals.  Brain Research, 963:139-149.

Fujisawa S and C Aoki (2003) In vivo blockade of N-methyl-D-aspartate receptors induces rapid trafficking of NR2B subunits away from synapses and out of spines and terminals in adult cortex. Neuroscience,121: 51-63. PMCID: PMC2874833

Levy R. B. and Aoki C. (2002). α7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and negative excitatory synapses in rat sensory cortex. J Neurosci., 22: 5001-5015.

Aoki C., Mkio I., Oviedo H., Mikeladze-Dvall T., Alexandre L., Sweeney N. and Bredt D. S. (2001). Electron microscopic immunocytochemical detection of PSD-95, PSD-93, SAP-102 and SAP-97 at postsynaptic, presynaptic and nonsynaptic sites of adult and neonatal rat visual cortex. Synapse, 40: 239-257.

Erisir A., Levey I., and Aoki C. (2001). Muscarinic receptor M2 in cat visual cortex: laminar distribution, relationship to GABAergic neurons and effect of cingulate lesions. J Comp Neurol., 441: 168-185.

Aoki C., Rodrigues S., and Kurose H. (1999). Use of electron microscopy in the detection of adrenergic receptors. In Methods in Molecular Biol: Adrenergic Receptor Protocols, 136: 537- 565, C Machida, ed., Humana.  https://link.springer.com/protocol/10.1385/1-59259-684-3:535. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882091/pdf/nihms-183851.pdf

Aoki C., Bredt D. S., Fenstemaker S., and Lubin M. (1998). The subcellular distribution of nitric oxide synthase relative to the NR1 subunit of NMDA receptors in the cerebral cortex. In Prog in Brain Res 118 Nitric Oxide in Brain Development, Plasticity, and Disease, RR Mize, TM Dawson, VL Dawson and MJ Friedlander, eds., 83-100.

Aoki, J. Rhee*, M. Lubin and T.M. Dawson. 1997. NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal NOS at pre- and postsynaptic sites and spines. Brain Res. 750:25-40.

Lubin M., Leonard C. S., and Aoki C. (1997). Preservation of ultrastructure and antigenicity for EM immunocytochemistry following intracellular recording and labeling of single cortical neurons in brain slices. J. Neurosci. Methods, 81: 91-102.

C. Aoki. (1997). Differential timing for the appearance of neuronal and astrocytic β-adrenergic receptors in the developing rat visual cortex as revealed by light and electron-microscopic immunocytochemistry, Vis. Neurosci., 14: 1129-1142. PDF

Aoki C., Lubin M., and Fenstemaker F.  (1994). Columnar regulation of β-adrenergic receptor-like immunoreactivity in monkey V1. Vis. Neurosci., 11: 179-187.

Aoki C (1992). beta-adrenergic receptors: astrocytic localization in the adult visual cortex and their relation to catecholamine axon terminals as revealed by electron microscopic immunocytochemistry.  J Neurosci 12(3): 781-792. PDF

Aoki C. and Kabak S. (1992). Cholinergic terminals in the cat visual cortex: Ultrastructural basis for interaction with glutamate-immunoreactive neurons and other cells.Vis. Neurosci., 8: 177-191.

Aoki C., Zemcik B.A., Strader C D and Pickel V.M. (1989) Cytoplasmic loop of beta-adrenergic receptors: synaptic and intracellular localization and relation to catecholaminergic neurons in the nuclei of the solitary tracts.  Brain Res 493: 331-347. PDF

Aoki C. and Siekevitz P.  (1988). Plasticity in brain development. Scientific American, 256(12): 56-64.

Aoki C, Joh T.H. and Pickel, V.M. (1987) Ultrastructural localization of beta-adrenergic receptor-like immunoreactivity in the cortex and neostriatum of rat brain.  Brain Research 437 (1987) 264-282. PDF

Additional publications can be found here.